Table 1. Results from random effects ANOVA tests (coefficient p-values) obtained by pooling data from all groups.
| Intervention | Strain | Radiation &Side |
Intervention* Radiation &Side |
Strain* Intervention |
Strain* Radiation &Side |
||
|---|---|---|---|---|---|---|---|
| Length | WT | - | 0.964 | 0.001 | - | - | 0.470 |
| OVX | - | 0.850 | 0.389 | - | - | 0.400 | |
| Tt.Ar | WT | - | 0.010 | 0.744 | - | - | 0.851 |
| OVX | - | 0.015 | 0.023 | - | - | 0.596 | |
| Ct.Ar | WT | - | 0.039 | 0.808 | - | - | 0.827 |
| OVX | - | 0.005 | 0.085 | - | - | 0.707 | |
| Ct.Ar/Tt.Ar | 0.133 | <0.001 | 0.244 | 0.417 | 0.857 | 0.632 | |
| Ct.Th | 0.810 | <0.001 | 0.521 | 0.418 | 0.604 | 0.281 | |
| Tb.BV/TV | B6 | 0.002 | - | 0.001 | 0.236 | - | - |
| BAL | 0.053 | - | 0.196 | 0.626 | - | - | |
| Tb.Th | 0.012 | 0.466 | 0.041 | 0.512 | 0.793 | 0.895 | |
| Tb.Sp | 0.001 | 0.140 | <0.001 | 0.872 | 0.775 | 0.365 | |
| Tb.N | 0.005 | <0.001 | <0.001 | 0.880 | 0.775 | 0.844 | |
| Total BMC | WT | - | 0.012 | 0.118 | - | - | 0.998 |
| OVX | - | 0.003 | 0.152 | - | - | 0.762 | |
| Strength | 0.573 | 0.016 | 0.425 | 0.765 | 0.780 | 0.324 | |
| Stiffness | 0.527 | 0.270 | 0.532 | 0.495 | 0.956 | 0.269 | |
Separate models were used where heteroskedasticity was identified from the full model (Levene’s test, p<0.05). For each variable the effect of three factors is reported (Intervention: WT vs OVX; Strain: C57BL/6 vs BALB/c; Radiation&Side: left non-irradiated vs right irradiated), as well as interactions between factors (indicated by *). Significant differences or significant interactions (p<0.05) are reported in bold. B6 = C57BL/6 mice, BAL = BALB/c mice, WT = wild type, OVX = ovariectomy. Parameters reported: length; trabecular parameters: bone volume fraction (Tb.BV/TV), thickness (Tb.Th), separation (Tb.Sp), number (Tb.N); cortical parameters: total area (Tt.Ar), cortical area (Ct.Ar), area fraction (Ct.Ar/Tt.Ar), thickness (Ct.Th); total bone mineral content (BMC); mechanical properties: stiffness, strength.