Table 2. Differences between right and left tibiae obtained by pooling data from all groups.
| L | R | Diff (95% CI) | SD | Diff [%] (95% CI) | ||
|---|---|---|---|---|---|---|
| Length [mm] | WT | 17.8 | 17.7 | -0.110 (-0.161, -0.059) | 0.076 | -0.61 (-0.90, -0.33) |
| OVX | 18.2 | 18.1 | -0.074 (-0.278, 0.130) | 0.266 | -0.41 (-1.53, 0.72) | |
| Tt.Ar [mm2] | WT | 0.847 | 0.845 | -0.002 (-0.017, 0.012) | 0.021 | -0.3 (-2.0, 1.4) |
| OVX | 0.917 | 0.871 | -0.046 (-0.079, -0.012) | 0.044 | -5.0 (-8.7, -1.3) | |
| Ct.Ar [mm2] | WT | 0.559 | 0.558 | -0.001 (-0.007, 0.005) | 0.009 | -0.1 (-1.2, 1.0) |
| OVX | 0.589 | 0.567 | -0.023 (-0.047, 0.001) | 0.031 | -3.8 (-7.9, 0.2) | |
| Ct.Ar/Tt.Ar [%] | 65.5 | 65.9 | 0.378 (-0.329, 1.085) | 1.51 | 0.6 (-0.5, 1.7) | |
| Ct.Th [μm] | 241 | 240 | -1.224 (-4.927, 2.479) | 7.91 | -0.5 (-2.0, 1.0) | |
| Tb.BV/TV [%] | B6 | 6.40 | 5.45 | -0.955 (-1.433, -0.476) | 0.71 | -14.9 (-22.4, -7.4) |
| BAL | 9.31 | 8.50 | -0.811 (-2.003, 0.381) | 1.55 | -8.7 (-21.5, 4.1) | |
| Tb.Th [μm] | 53.7 | 55.4 | 1.765 (0.219, 3.312) | 3.30 | 3.3 (0.4, 6.2) | |
| Tb.Sp [μm] | 358 | 400 | 41.737 (23.383, 60.092) | 39.2 | 11.6 (6.5, 16.8) | |
| Tb.N [1/mm] | 1.43 | 1.23 | -0.203 (-0.290, -0.116) | 0.185 | -14.2 (-20.3, -8.1) | |
| Total BMC [mg] | WT | 11.0 | 11.2 | 0.185 (-0.040, 0.410) | 0.335 | 1.7 (-0.4, 3.7) |
| OVX | 11.7 | 11.3 | -0.364 (-0.843, 0.115) | 0.622 | -3.1 (-7.2, 1.0) | |
| Strength [N] | 14.2 | 14.7 | 0.489 (-0.953, 1.931) | 3.08 | 3.4 (-6.7, 13.6) | |
| Stiffness [N/mm] | 167 | 171 | 3.836 (-13.557, 21.230) | 37.2 | 2.3 (-8.1, 12.7) | |
Estimated marginal means from random effects ANOVA models for parameters measured in left (L, non-irradiated) and right (R, irradiated) tibiae, with estimated effect of Radiation&Side. Where the full model indicated a significant interaction, or a non-constant variance between groups, separate ANOVA models were used. B6 = C57BL/6 mice, BAL = BALB/c mice, WT = wild type, OVX = ovariectomy. Parameters reported: length; trabecular parameters: bone volume fraction (Tb.BV/TV), thickness (Tb.Th), separation (Tb.Sp), number (Tb.N); cortical parameters: total area (Tt.Ar), cortical area (Ct.Ar), area fraction (Ct.Ar/Tt.Ar), thickness (Ct.Th); total bone mineral content (BMC); mechanical properties: stiffness, strength.