Table 3. Trends in differences between right and left tibiae for each group.
| Group | Length [mm] | Tt.Ar [mm2] | Ct.Ar [mm2] | Ct.Ar/ Tt.Ar [%] |
Ct.Th [μm] | Tb. BV/TV [%] |
Tb.Th [μm] | Tb.Sp [μm] | Tb.N [1/mm] | BMC [mg] | Stiffness [N/mm] |
Strength [N] |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| B6- WT (N = 6) |
L | 17.9 ± 0.3 |
0.90 ± 0.05 | 0.55 ± 0.03 | 60 ± 1 |
216 ± 9 |
7.9 ± 1.3 |
56 ± 4 |
323 ± 47 |
1.39 ± 0.29 | 10.61 ± 0.90 |
161 ± 36 |
15 ± 4 |
| R | 17.8 ± 0.3 | 0.89 ± 0.04 | 0.55 ± 0.04 | 61 ± 2 |
218 ± 12 |
6.6 ± 0.7 |
58 ± 5 |
400 ± 65 |
1.12 ± 0.19 | 10.70 ± 0.87 | 151 ± 18 |
15 ± 2 |
|
| Diff [%] | -0.5±0.5 | -1 ± 2 | -1 ± 1 | 0 ± 3 | 0 ± 2 | -10 ± 11 | 2 ± 5 | 11 ± 14 | -15 ±12 | 1 ± 4 | -8 ± 23 | 0 ± 28 | |
| B6- OVX (N = 5) |
L | 18.1 ± 0.2 |
0.97 ± 0.05 |
0.56 ± 0.04 |
58 ± 2 |
212 ± 13 |
5.8 ± 0.9 |
52 ± 3 |
404 ± 54 |
1.06 ± 0.13 |
10.88 ± 0.95 |
166 ± 20 |
16 ± 2 |
| R | 18.1 ± 0.2 |
0.90 ± 0.05 |
0.53 ± 0.03 |
59 ± 1 |
204 ± 8 |
4.2 ± 0.5 |
49 ± 6 |
439 ± 46 |
0.80 ± 0.08 |
10.34 ± 0.78 |
172 ± 32 |
16 ± 3 |
|
| Diff [%] | -0.5±1.5 | -6 ± 5 | -4 ± 6 | 2 ± 3 | -1 ± 5 | -24 ± 8 | 5 ± 9 | 9 ± 11 | -24 ± 10 | -1 ± 7 | 2 ± 15 | 0 ± 14 | |
| BAL- WT (N = 5) |
L | 17.8 ± 0.2 |
0.80 ± 0.03 |
0.57 ± 0.04 |
73 ± 3 |
271 ± 19 |
10.4 ± 2.4 |
56 ± 4 |
324 ± 25 |
1.66 ± 0.41 |
11.48 ± 1.11 |
175 ± 20 |
12 ± 1 |
| R | 17.6 ± 0.2 |
0.79 ± 0.05 |
0.57 ± 0.04 |
74 ± 2 |
276 ± 13 |
10.1 ± 1.3 |
58 ± 1 |
344 ± 10 |
1.71 ± 0.25 |
11.97 ± 1.08 |
177 ± 43 |
15 ± 3 |
|
| Diff [%] | -0.8±0.3 | 0 ± 3 | -1 ± 2 | 0 ± 3 | 2 ± 4 | -16 ± 18 | 4 ± 6 | 6 ± 8 | -17 ± 15 | 2 ± 3 | 8 ± 29 | 18 ± 21 | |
| BAL- OVX (N = 4) |
L | 18.3 ± 0.3 |
0.86 ± 0.03 |
0.62 ± 0.01 |
72 ± 1 |
276 ± 5 |
7.8 ± 1.6 |
52 ± 3 |
379 ± 53 |
1.51 ± 0.23 |
12.69 ± 0.42 |
169 ± 29 |
13 ± 1 |
| R | 18.0 ± 0.3 |
0.83 ± 0.04 |
0.61 ± 0.02 |
73 ± 2 |
277 ± 7 |
7.5 ± 0.6 |
54 ± 0 |
410 ± 38 |
1.40 ± 0.11 |
12.52 ± 0.50 |
197 ± 35 |
14 ± 2 |
|
| Diff [%] | -0.6±1.4 | -5 ± 5 | -3 ± 4 | 2 ± 1 | 0 ± 1 | -3 ± 12 | 3 ± 6 | 10 ± 14 | -6 ± 7 | -2 ± 2 | 2 ± 20 | 7 ± 13 |
Trends in differences (median ± SD) between right (R, irradiated) and left (L, non-irradiated) tibiae. B6 = C57BL/6 mice, BAL = BALB/c mice, WT = wild type, OVX = ovariectomy. Parameters reported: length; trabecular parameters: bone volume fraction (Tb.BV/TV), thickness (Tb.Th), separation (Tb.Sp), number (Tb.N); cortical parameters: total cross-sectional area (Tt.Ar), cortical area (Ct.Ar), area fraction (Ct.Ar/Tt.Ar), thickness (Ct.Th); total bone mineral content (BMC); mechanical properties: stiffness, strength.