Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Nov 15;10:1371. doi: 10.3389/fphar.2019.01371

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Wang, Liu, Huang, Zheng, Wang, Yang, Situ, Lin and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

XIAOPI formula (XPS) suppresses breast cancer stem cells (CSCs) by modulating tumor-associated macrophages (TAMs)/C-X-C motif chemokine ligand 1 (CXCL1) pathway. (A-B) CXCL1 stimulation for 48 h could abrogate the inhibitory effect of XIAOPI formula on breast CSCs subpopulations and mammospheres formation abilities in the co-cultured breast cancer cells. Scale bar = 100 μm. (C) QPCR assay suggested that CXCL1 stimulation for 48 h could abrogate the inhibitory effect of XIAOPI formula on mRNA expression levels of stemness-related genes including β-catenin, OCT4, and Nanog in the co-cultured breast cancer cells. (D) Western blot assay further convinced that CXCL1 treatment for 48 h could reverse the inhibitory effect of XIAOPI formula on β-catenin expression in the co-cultured breast cancer cells. All values are presented as the mean ± SD, n = 3, **P < 0.05.