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. 2019 Nov 8;10:769. doi: 10.3389/fendo.2019.00769

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Copyright © 2019 Kari, Vasko, Priya and Kirschner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LKB1 knockdown suppresses PKA-mediated AMPK activation. (A) LKB1-specific siRNA pool causes knockdown of LKB1 in FTC−133 cells. Non-targeting siRNA was used as a control. Proteins were analyzed 48 h after transfection. Vinculin is shown as a loading control. (B) Cells treated with control- or LKB1-specific siRNAs were treated with PKA activator (PKA) and/or inhibitor (PKI) for the indicated times and probed for activation (phosphorylation) of mTOR, LKB1, and AMPK. GAPDH was used as a loading control.