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. 2019 Nov 14;9:1244. doi: 10.3389/fonc.2019.01244

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Copyright © 2019 Zhang, Sun, Hao, Diao, Wang, Li, Cao and Mi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FAM53A inhibits proliferation, migration, and invasion in p53-wild-type breast cancer cells. (A) MCF-7 cells were transfected with FAM53A-specific (si-FAM53A) or control (NC) siRNA, or with a FAM53A expression (p-FAM53A) or vehicle (p-NC) plasmid. Western blotting was performed to evaluate transfection and silencing efficiency. (B) Representative images and quantification of colony formation assays. (C) MTT assay results. (D) Expression changes in proliferation-related proteins. (E) Cell invasion and migration assays. (F) Expression of proteins associated with cell migration and invasion. For all panels, *P < 0.05; **P < 0.01.