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. 2019 Sep 11;3(11):e10227. doi: 10.1002/jbm4.10227

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© 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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(A, B) Representative 5‐bromo‐2′‐deoxyuridine (BrdU) images of the region of interest from nonloaded and loaded tibias in 12‐month‐old mice. (C, D) 40× magnifications from loaded tibias. (E) Total Ps.Osx⁺ (periosteum osterix positive) BrdU ⁺ surface increase with loading. (F) Ps.Osx⁺ BrdU ⁺ cells increase with loading. Data shown as mean ± SD (n = 10; males = 6, females = 4). * Signifies p < .05 by Student's t test. tdTomato = red; calcein = green; BrdU = white; 4,6‐diamidino‐2‐phenylindole (DAPI) = blue; Mu = muscle; Ps = periosteum; B = bone.