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. 2019 Nov 22;14(11):e0224071. doi: 10.1371/journal.pone.0224071

Fig 1. Volcano plot of miRNA-microarray.

Fig 1

The volcano plot exhibits the relationship between fold-change and significance between the two groups, using a scatter plot view. The y-axis is the negative log2 of P values (a higher value indicates greater significance) and the x-axis is the difference in expression between two experimental groups as measured in log2 space. The blue dots in the figure represents individual miRNAs differentially expressed in four prostate cancer cell lines LNCaP (early-stage), PC3, DU145 (advanced-stage) and 22Rv1 (castration resistant prostate cancer; CRPC). The vertical dotted lines correspond to p value < 0.01 and <0.001, respectively. The horizontal dotted line represents a log 2 fold changes. The left side in the panel corresponds to differentially expressed miRNAs with decreased expression, and the right side in the panel showed miRNA with increased expression.