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. 2019 Nov 22;14(11):e0225624. doi: 10.1371/journal.pone.0225624

Fig 3. Immune cell infiltration of grafts in IL-21-/- mice in a chronic rejection model.

Fig 3

A) Representative images of IHC stained vessels in grafts of heart transplants from bm12 mice in WT or IL-21-/- recipient mice (n = 3 mice/group). Stains were as follows: MAC2, macrophages; CD3, T-cells; B220, B-cells. B) Organization of CD3 stained T-cells and B220 stained B-cells near vessel with possibility of tertiary lymphoid organ like development. C) Accumulation of immune cells detected by flow cytometry of spleen homogenates. Significance approximated by unpaired Student’s t-test, * indicates p < 0.05.