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. Author manuscript; available in PMC: 2019 Nov 22.
Published in final edited form as: ACS Chem Biol. 2018 Sep 20;13(10):2908–2919. doi: 10.1021/acschembio.8b00533

Figure 2 |. Drug leads in which the phosphate group was replaced by a carboxylic acid.

Figure 2 |

(A) A carboxylic group in place of the phosphate group only results in a minor drop in binding and activity. Color-coding for functional groups: green, as in Figure 1; orange, negatively charged/polar group introduced during SAR study (raw and normalized data in Tables S1 and S2;Figure S1). (B) Banding pattern of SHAPE chemical probing within the J6/1 joining region for compounds shown in panel (A), as in Figure 1 (full unaltered SHAPE gels shown in Figure S2).