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. Author manuscript; available in PMC: 2019 Nov 22.
Published in final edited form as: ACS Catal. 2018 Jun 4;8(7):5947–5951. doi: 10.1021/acscatal.8b01341

Table 2.

Scope of β-Alkyl, β-Fluoro Michael Acceptors

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a

Standard reaction conditions: 0.5 mmol 2–15a, 3.0 equiv Et3N·3HF, 1.0 equiv p-CI BA, 5 mol % RuPhosAuCl, 5 mol % AgBF4, 4:1 MeCN:CH2CI2 [0.7M], rt, 24 h.

b

2-15b isolated as a single isomer except 11b.

c

Detemined by 19F NMR spectroscopy with PhF as an internal standard.

d

6.0 mmol scale.

e

5.0 mmol scale.

f

55 °C ginsoluble product.

h

1.25 M, 4.0 equiv Et3N·HF.

i

1.25 M, 4.0 equiv Et3N·3HF.

j

1.43 M, 4.5 equiv Et3N·3HF, 50 °C.