Figure 5.

Effects of the exposure of H295R cells with A) anastrozole (ATZ) (black dashed line), 1, 2, 3, 5 and B) letrozole (LTZ) (black dashed line), Ru-LTZ on aromatase activity. Cells were treated for 1.5 h with the indicated concentrations of the compounds. Values represent the mean ± SD. Significant differences for aromatase activity are reported relative to the controls. Significant differences (p < 0.001): 14±4% for 3 at 1000 nM vs 34±7% for ATZ at 40 nM; 47±3% for 3 at 100 nM vs 74±3% for ATZ at 4 nM (ATZ results obtained from interpolation).