Table 1.
Triazole-gold catalyzed A3 reaction.
 | ||||
|---|---|---|---|---|
| Entry | Varieties from standard condition a | Yield b |
||
| 1a convn. | 4 | 5 | ||
| 1 | None | 100% | 0% | 90% |
| 2 | room temperature | 39% | 37% | 0% |
| 3 | 60°C | 60% | 36% | 22% |
| 4 | 5% PPh3AuNTf2 | 100% | <5% | 79% |
| 5 | 5% PPh3AuCl/AgOTf | 100% | <5% | 67% |
| 6 | 5% AuCl | <10% | – | – |
| 7 | 5% AuCl3 | <10% | – | – |
| 8 | 5% PyAuCl2 | <10% | – | – |
a
Standard condition: 5 mol% catalyst, 1a (1.1 mmol), 2a (1.0 mmol), and 3a (1.0mmol) in toluene (1 mL). The reaction mixture was stirred at 110°C for 24h.
b
Yield and conversion was determined by 1H NMR using 1, 3, 5-trimethox-ybenzene as internal standard.