Figure 3. Individual specific relationship between EF and volume change in the hippocampus.

Left: Scatterplot of EF versus volume change in the hippocampus (t = 5.97, df = 300, r = 0.33, p < 0.0001, left and right side together). There is a significant relationship on the left side (orange dots; t = 4.53, df = 149, r = 0.35, p < 0.0001), but not on the right side (probably due to ceiling effect) (t = 1.59, df = 149, r = 0.13, p = 0.11). Right: The difference in right and left hippocampal volume changes is significant (t = 7.76, df = 150, mean difference = 0.011, p < 0.0001).

Figure 3—figure supplement 1. Hippocampal EF and volume change.

To test the specificity of our measures in the left hippocampus (FDR corrected finding) we permutated the labels across the 85 ROIs, both for the volume changes (left) and for the EF values (right) and calculated correlations between the EF and volume change of these regions, respectively. This way we received 85 different values, where one of them was the ‘correct’ correlation, indicated with red dots. The ‘correct’ correlations between the EF and corresponding volume outperformed the other correlations (were in the top five percentile) from non-matching pairs, indicating that our findings were not merely a general correlation with some average values across regions, further strengthening the casual link between EF and volume change.