Table 1. Basic characteristics of poly(lactic-co-glycolic acid) NP, TG-loaded NP and KIM-1-TG-loaded NP.
PLGA NP | TG-PLGA NP | KIM-1-TG-PLGA NP | |
Hydrodynamic diameter (nm) | 105.2 | 110.5 | 200.4 |
PDI | 0.204 | 0.234 | 0.221 |
Zeta potential (mV) | −35.2 | −36.3 | −38.6 |
Real diameter (nm) | 90.1 | 91.3 | |
Encapsulation efficiency (μg TG/ mg PLGA) | 34 | 34 |
PLGA: Poly(lactic-coglycolic acid); TG NP: Thapsigargin-encapsulated PLGA nanoparticle; KIM-1: Kidney injury molecule-1; KIM-1-TG NP: KIM-1 antibody-conjugated TG-PLGA NP; PDI: Polydispersity index.