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. 2019 Nov 9;11(21):9738–9766. doi: 10.18632/aging.102422

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Copyright © 2019 Zhong et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) Protein-protein interaction (PPI) network of genes in the blue module. Every edge represented the interaction between two genes. Module 1 and module 2 were the top 2 modules from the PPI network. Yellow nodes noted hub nodes. (B) Based on the Murat and Lee study, AURKA and KDR mRNA expression were significant up-regulated in GBM tissues compared with normal brain tissue (p<0.01). (C) Kaplan-Meier estimated overall survival (OS) days in GBM patients. Left panel showed low-expressed KDR had significantly longer OS days (p=0.01). Right panel showed low-expressed AURKA had significantly longer OS days (p=0.01). (D) DNA copy number of AURKA. (E) Gene set enrichment analysis (GSEA) showed that cell cycle pathway (p=0.007, FDR=23.8%) and VEGF pathway (P=0.015, FDR=25.3%) were abnormally regulated in GBM tissues compared with normal brain tissue. (F) Functional and pathway enrichment analysis of genes in blue module.