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. 2019 Nov 9;11(21):9738–9766. doi: 10.18632/aging.102422

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Copyright © 2019 Zhong et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) Transmission Electron Microscope (TEM) images showed that ENMD-2076 induces apoptosis bodies and pyknosis formation in U87 cells. (B–C) Flow cytometry showed that ENMD-2076 induced cell cycle arrest in G2-M phase for LN18, T98G cells. (D) Western blot analysis showed that ENMD-2076 increased the expression of Caspase-3 and Bax in LN18, T98G cells and decreased the expression of anti-apoptotic Bcl-2. Western blot analysis also showed the effects of ENMD-2076 on the phosphorylation levels of Cdc2, cyclin B1 and cyclin D1 in LN18 and T98G cell lines. (E) Western blot analysis showed that ENMD-2076 suppressing PI3K/Akt/mTOR signaling pathway in LN18, T98G cells.