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. 2019 Nov 9;11(21):9738–9766. doi: 10.18632/aging.102422

Table 1. Functional and pathway enrichment analysis of the genes in blue module.

Category Term Count % PValue
GOTERM_BP_DIRECT GO:0007268~chemical synaptic transmission 36 8.49 1.56E-19
GOTERM_BP_DIRECT GO:0007067~mitotic nuclear division 23 5.42 1.82E-08
GOTERM_BP_DIRECT GO:0034765~regulation of ion transmembrane transport 15 3.54 1.01E-07
GOTERM_BP_DIRECT GO:0006813~potassium ion transport 13 3.07 1.59E-07
GOTERM_BP_DIRECT GO:0017157~regulation of exocytosis 8 1.89 8.76E-07
GOTERM_CC_DIRECT GO:0030054~cell junction 47 11.08 1.17E-18
GOTERM_CC_DIRECT GO:0030425~dendrite 30 7.08 1.51E-10
GOTERM_CC_DIRECT GO:0048786~presynaptic active zone 11 2.59 2.26E-10
GOTERM_CC_DIRECT GO:0045211~postsynaptic membrane 23 5.42 8.23E-10
GOTERM_CC_DIRECT GO:1902711~GABA-A receptor complex 9 2.12 1.37E-09
GOTERM_MF_DIRECT GO:0004890~GABA-A receptor activity 9 2.12 2.18E-09
GOTERM_MF_DIRECT GO:0005230~extracellular ligand-gated ion channel activity 9 2.12 3.10E-07
GOTERM_MF_DIRECT GO:0005524~ATP binding 61 14.39 7.72E-07
GOTERM_MF_DIRECT GO:0015467~G-protein activated inward rectifier potassium channel activity 5 1.18 3.65E-05
GOTERM_MF_DIRECT GO:0003777~microtubule motor activity 10 2.36 4.53E-05
KEGG_PATHWAY hsa05033:Nicotine addiction 15 3.54 5.62E-14
KEGG_PATHWAY hsa04723:Retrograde endocannabinoid signaling 20 4.72 4.40E-13
KEGG_PATHWAY hsa05032:Morphine addiction 16 3.77 1.04E-09
KEGG_PATHWAY hsa04727:GABAergic synapse 15 3.54 3.89E-09
KEGG_PATHWAY hsa04080:Neuroactive ligand-receptor interaction 23 5.42 1.61E-07