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. 2019 Oct 15;37(12):850–859. doi: 10.1007/s11604-019-00886-4

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — The case of tumor enlargement during stereotactic radiotherapy. The case was brain metastasis of which primary tumor was skin melanoma. Orange line shows the gross tumor volume (GTV) of the initial plan, and red line shows GTV at the modification. The enlargement of cystic component was observed. a, b Axial, Sagittal: T1-weighted magnetic resonance imaging (MRI) with gadolinium (Gd) of the initial plan. c, d Axial, Sagittal: T1-weighted MRI with Gd before fourth treatment for the modification (the 6th day of SRT start)