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. 2019 Nov 22;9:17363. doi: 10.1038/s41598-019-53915-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Number and size of colonies and number of primary and secondary tumorspheres. (A) (+)-JQ1, NVS-CECR2-1, GSK343, UNC1999 and A-196 decreased the number of colonies in comparison to the control (DMSO) formed in soft agar assay. (B) Only (+)-JQ1 decreased the diameter of colonies in comparison to the control (DMSO). Only ≥50 µm colonies were counted. (C) (+)-JQ1 and NVS-CECR2-1 inhibit tumorsphere formation in low-adherent plates. No difference was observed to tumorspheres treated with GSK343, UNC1999, and A-196 in comparison to the control (DMSO). (D) GSK343, UNC1999 and A-196 were also unable to inhibit the formation of secondary tumorspheres. (*p < 0.05; **p < 0.01; ****p < 0.0001; - One-way ANOVA followed by Tukey’s multiple comparison test).