Table 1.

Scope of enoldiazoacetates: effect of the R-substituent.

Entrya	R	Yield 3 (%)b	ee (%)c
1	Me	3b 82	75
2	Et	3c 92	90
3d	Bn	3d 73	90
4d	iPr	3e 70	92
5d	n-C8H17	3f 63	97

^aAll reactions were carried out on a 0.20 -mmol scale in 4.0 mL of DCM: 2a (0.20 mmol), 1a (0.24 mmol)

^bIsolated yield after flash-chromatography

^cDetermined by chiral HPLC analysis

^dReaction time was 72 h