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. 2019 Nov 22;9:17368. doi: 10.1038/s41598-019-53415-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Aβ-GFP Tg mice exhibit the impairment in long-term potentiation. (A) There are no significant difference in the slopes of the input-output relationship curve in the Schaffer collateral - CA1 synapses in Aβ-GFP Tg (n = 32 slices from 7 mice) and non-Tg (n = 33 slices from 7 mice) mice at 2-month-old. (B) Paired-pulse ratios of CA1 synapse fEPSPs in Aβ-GFP Tg (n = 32–33 slices from 7 mice) and non-Tg (n = 32–33 slices from 7 mice) mice at 2-month-old. Paired-pulse facilitation was negatively affected in the Aβ-GFP Tg mouse slices (***p = 0.0001 at 20 ms; p = 0.0006 at 50 ms; p = 0.0002 at 100 ms; p = 0.0009 at 200 ms; p = 0.0002 at 500 ms). (C) Theta burst stimulation induced LTP was impaired in Aβ-GFP Tg (n = 19 slices from 6 mice) compared to non-Tg (n = 16 slices from 7 mice, p < 0.001) mouse slices.