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. 2019 Nov 22;9:17368. doi: 10.1038/s41598-019-53415-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Synaptic expression of Aβ-GFP fusion protein and morphological changes in synapses in Aβ-GFP Tg mice. (A–C) Representative Immuno-EM image by anti-GFP antibody in Aβ-GFP Tg mice hippocampus at 3-month-old. The dotted rectangle in (A) are shown at higher magnification in (B) and (C). (D) Histograms representing the numbers of immunopositive synaptic structures per unit areas of stratum-radiatum in the hippocampal CA1 region. Aβ-GFP fusion protein was expressed mainly in the post synaptic sites (*p < 0.05, ***p < 0.0050, ****p < 0.0001 by one way ANOVA, n = 24 areas, data are presented as means ± SEM). (E) Golgi staining of apical dendrite from non-Tg and Aβ-GFP Tg mice hippocampal CA1 regions. Arrows showed spine and arrow heads showed filopodia. Compared to the non-Tg, Aβ-GFP Tg mice had significantly fewer spines and significantly more filopodia (****p < 0.0001 by Student’s t-test, n = 5 animals each, 20 μm length of dendrites from 24–27 areas each, data are presented as means ± SEM).