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. 2019 Nov 22;9:17368. doi: 10.1038/s41598-019-53415-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Aβ-GFP Tg mice exhibit the memory impairment both in young (3 months) and aged (18 months) mice. (A–C): Exploratory behavior in the open-field was measured in 18- month-old by locomotor activities (A,B) and the total number of rearings (C) over 10 min. Data are expressed as means ± SEM. (n = 11 each). There were no impairments in the OFT, indicating that exploratory behavior and locomotor activity were intact in aged Aβ-GFP Tg mice.(D,E): Apparatuses and the objects used for the NORT (D) and schematic representation of sample and test phase conditions in the NORT (E). (F,G): Impairment of object recognition memory in young (2–3 months) (F) and aged (18 months) (G) Aβ-GFP Tg mice. Dotted lines indicate chance performance (0.5). Data are presented as means ± SEM. ^#p < 0.05; unpaired t-test to evaluate difference between Aβ-GFP Tg and non-Tg mice, ***p < 0.001, **p < 0.01, * p < 0.05; one-sample t-test for the PI compared with chance performance (test value = 0.5).