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. 2019 Nov 22;9:17370. doi: 10.1038/s41598-019-53960-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Biosensor response to thiolated DNA aptamer Conductance vs. time plots of bare (a) and Au NP decorated (b) single ZnO NW devices upon introduction (arrows) of 10 µL of the indicated solution. The negatively charged thiolated DNA aptamer binds to the Au NPs on the NW surface, inducing positive charges and decreasing the ZnO NW conductivity; in contrast, DNA is unable to bind to the unmodified NW surface and solution introduction has no effect on conductivity.