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. 2019 Nov 22;5:25. doi: 10.1038/s41531-019-0099-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Changes in MDS-UPDRS-III subdomains from OFF to ON medication state in each study group. Empty bars indicate OFF medication scores for each subdomain; superimposed filled bars indicate ON medication scores after levodopa challenge. Study group is indicated by the colors red, blue, and purple for the NO-FOG, OFF-FOG, and ONOFF-FOG groups, respectively. Subdomains are sorted in ascending order of group effect P value from left to right. Maximum subdomain scores are 4 points (/4) unless noted. †Significant effect of medication state (OFF vs. ON), P < 0.05, RM-ANOVA. *,**Significant effect of group, *P < 0.05, **P < 0.01. ‡Significant state × group interaction, P < 0.05.