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. 2019 Nov 22;2:427. doi: 10.1038/s42003-019-0671-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Taxol suppresses microtubule growth and elongation in larval brain NBs. a EB1-EGFP and CD8-GFP-labeled control (No Taxol) and Taxol-treated (+Taxol) BLs. Activated NBs (NB, pink) in control BLs (left) in prophase (top left, pink arrow) or mitosis (white arrows). NBs in Taxol-treated BLs (right) in prophase (yellow arrow) or mitosis (magenta arrows). Abnormal NB (Abn NB, yellow). b Plot, NBs in Taxol-treated BLs (+Tx; 2.5 ± 1.35 NBs/BL, mean ± SD, n = 25, n = 10 BLs) are reduced in frequency compared with controls (No Tx; 7.75 ± 1.71 NBs/BL, n = 31, n = 4 BLs; ***, P < 0.001, unpaired t-test). c Time-lapse images of control NBs in prophase (top) with the centrosome (cyan arrows) slightly above or below the plane of focus, or mitosis (bottom), showing rapid growth of single microtubules (green and magenta v’s; Supplementary Movies 3 and 4). d Taxol-treated NBs in prophase (top) with a small centrosome and faintly labeled microtubules (orange arrowheads) near the nucleus (black sphere) or in mitosis (bottom) with a rudimentary spindle (yellow arrowheads) and no growing or elongating microtubules (Supplementary Movies 5 and 6). Time, min:s. Bars, 6 µm (a); 3 µm (b, c).