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. 2019 Nov 22;9:17380. doi: 10.1038/s41598-019-53850-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Single nucleotide polymorphism analysis reveals the evolutionary relationship between clones and the relative abundance of each within the U87MG cell line. (A) Phylogenetic inference using LICHEeE demonstrates a close relationship of clones D and E, while clone C shows the greatest difference in genetic phenotype to all other clones. (Nodes (grey) represent the number of SNPs shared between sets of samples and edges represent ancestry relationships). (B) Principal component analysis of the genotype annotations indicates that the U87MG cell line is largely composed of clones D and E as well as genetically similar clones, while clone C is likely to make up a small fraction of cells within that cell line.