Table 1.
Top three KEGG enriched pathways within the highest and lowest (phospho)protein abundance quartiles for each clonal subtype.
| Regulation | Subtype | % proteins measured | Pathway 1 | Pathway 2 | Pathway 3 |
|---|---|---|---|---|---|
| upregulated | 1 | 4% | Ras signaling | Rap1 signaling | Endocytosis |
| 2 | 3% | — | — | — | |
| 3 | 40% | Prolactin signaling | Proteoglycans in cancer | ErbB signaling | |
| 4 | 15% | Focal adhesion | Natural kill cell mediated cytotoxicity | MicroRNAs in cancer | |
| 5 | 15% | PI3K-Akt signaling | Ras signaling | FoxO signaling | |
| 6 | 72% | ErbB signaling | FoxO signaling | Proteoglycans in cancer | |
| downregulated | 1 | 3% | Focal adhesion | Regulation of actin skeleton | — |
| 2 | 18% | Proteoglycans in cancer | Ras signaling | Pathways in cancer | |
| 3 | 7% | McroRNAs in cancer | MAPK signaling | PI3K-Akt signaling | |
| 4 | 41% | PI3K-Akt signaling | FoxO signaling | Pathways in cancer | |
| 5 | 47% | ErbB signaling | Prolactin signaling | T cell receptor signaling | |
| 6 | 4% | Focal adhesion | Regulation of actin skeleton | Proteoglycans in cancer |