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. 2019 Nov 22;2:428. doi: 10.1038/s42003-019-0678-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — B. pseudomallei disease- and environmental-associated genes. a Bar charts summarise the frequency of disease- or environment- associated genes by functional category. The plots are ranked by categorical gene frequency from unknown category (n = 13 genes), potential roles in pathogenicity (n = 13 genes), replication, recombination and repair (n = 13 genes), cell wall membrane envelope biogenesis (n = 3 genes), secondary metabolite biosynthesis (n = 3 genes), and energy production and conservation (n = 2 genes). b Distance network reveals genetic loci enriched in disease- and environment-associated isolates. A network was constructed on distance between disease and environmental-associated genes that fell within the size of operon described by the transcriptional unit, as reported in Ooi et al. 2013. Each node represents each gene, with the edge thickness proportional to the frequency of each gene pair observed in the population. The largest disease-associated locus identified in this dataset was the toxin complex. For a and b, the colour indicates the effect size and directionality of association on the scale of log₁₀(Odds ratio), with red and blue presenting association with disease and the environment, respectively.