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. 2019 Nov 22;9:17382. doi: 10.1038/s41598-019-54034-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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22 hour locomotor activity was altered between aSyn transgenic (tg) and wild type (wt) littermates in all age groups. At 3 months, significant changes between tg and wt animals were not seen (A). 6, 9, and 12 months old tg mice were more active compared to wt littermates right after the lights were turned off but less active than wt mice between 22:00 and 1:00 (B–D). 18 months old tg mice were more active during the dark time compared to wt littermates (E). When comparing locomotor activity during the first hour of the locomotor experiment, tg mice showed increased activity only at the age of 12 months (F). Data are expressed as mean ± SEM, n = 7–23. Repeated measures 2-way-ANOVA, (A–E); Student’s t-test (F); *p < 0.05, **p < 0.005, ***p < 0.001.