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. 2019 Nov 22;9:17382. doi: 10.1038/s41598-019-54034-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of total distance travelled, vertical counts, jump count, and average speed during 22 h locomotor activity measurements between aSyn transgenic mice (tg) and wild type littermates (wt). Total distance travelled was decreased in 9 months and increased in 18 months old tg mice compared to wt mice (A). 3 and 6 months old tg mice showed significantly less vertical counts compared to littermates (B). 12 old months tg mice had more vertical counts compared to wt mice (B). Jump counts were significantly lower in 3, 6, and 9 months old tg mice compared to wt littermates (C). Average speed of tg mice was significantly lowered in all age groups (D). Data are expressed as mean ± SEM, n = 7–23. Student’s t-test, *p < 0.05, **p < 0.005, ***p < 0.001, ****p < 0.0001.