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. 2019 Nov 22;9:17382. doi: 10.1038/s41598-019-54034-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Amphetamine-induced locomotor activity was increased in the aSyn transgenic animals (tg) compared to wild-type (wt) littermates. After amphetamine administration, increased activity in tg mice was seen at the 6 and 18 month time-points, while only initial locomotor activity was increased in 9 months old tg animals (A–E). Total travelled distance of tg mice was increased in all age groups during the initial 5 minutes of the locomotor activity test compared to wt littermates (F). Data are expressed as mean ± SEM; n = 7–23. Repeated measures two-way ANOVA(A–E), Student’s t-test (F); *p < 0.05, **p < 0.01, ***p < 0.001.