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. 2019 Nov 22;9:17382. doi: 10.1038/s41598-019-54034-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Striatal extracellular concentrations of dopamine (DA), its main metabolites DOPAC and HVA, 5-HIAA, and GABA were measured in the 12 months old and 18 months old wildtype (wt) and aSyn transgenic (tg) mice by microdialysis. Baseline level of DA (A), its metabolites (B), or GABA (D) were not changed but 5-HIAA was increased in both 12 months old and 18 months old tg mice (C). Amphetamine-induced increase in extracellular dopamine was lowered in the 12 months old tg mice with 30 µM d-amphetamine sulphate (AMPH) and there was a similar trend with 10 µM AMPH (E) but there was no difference between 18 months old mice (F). Data are expressed as mean ± SEM; 12 months: n = 10–12/group, 18 months: n = 7–8/group. Student’s t-test (A-D), repeated measures ANOVA (E-F); *p < 0.05.