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. 2019 Nov 22;9:17382. doi: 10.1038/s41598-019-54034-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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18 months old aSyn transgenic (tg) animals showed changes in DA, its metabolites, 5-HT, GABA and glutamate in the striatum. Striatal tissue concentrations of neurotransmitters and their metabolites were measured in the 12 months and 18 months old tg mice and their wild-type (wt) littermates. There was no alteration in neurotransmitters or their metabolites in the 12 months old mice (A–F). Dopamine was decreased in the striatum of 18 months old tg mice compared to wt littermates (A) and there was a similar trend in the dopamine metabolites (B). 5-HT (C), GABA (E) and glutamate (F) levels were increased in 18 months old tg mice but 5-HIAA was not changed (D). GABA (E) and GLU (F) had an age-dependent decrease in Wt mice but a similar phenomenon was not observed in other neurotransmitters in tg mice. Data are expressed as mean ± SEM; 12 months: n = 10–12/group, 18 months: n = 8/group. Student’s t-test, *p < 0.05; ***p < 0.001.