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. 2019 Nov 22;9:17382. doi: 10.1038/s41598-019-54034-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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aSyn transgenic (tg) mice had significantly decreased TH and increased oligomer specific aSyn (aSyn OS) immunoreactivity in the striatum (STR) and substantia nigra (SN). Representative images of TH and aSyn OS staining from the striatum and substantia nigra of 12 and 18 month old wt and tg mice (A). TH optical density (OD) was significantly decreased in the STR and SN of 12 and 18 month old tg mice (B,C). OD of aSyn OS was significantly increased in both STR and SN at 12 and 18 months (D,E). Data are expressed as mean + SEM; n = 8–18. Student’s t-test,* p < 0.05, **p < 0.005, ****p < 0.0001.