. 2019 Nov 22;9:17385. doi: 10.1038/s41598-019-53749-3

Table 1.

Multivariate logistic regression models.

Predictor variable	Full model	Odds ratio (95%CI); p-value	Model excluding SOZ
Age (years)	1.04 (0.96 to 1.13); p = 0.30	1.02 (0.95 to 1.10); p = 0.59	1.05 (0.98 to 1.13); p = 0.20
Gender (1 if male; 0 female)	1.36 (0.49 to 3.78); p = 0.56	1.19 (0.47 to 3.01); p = 0.71	1.44 (0.59 to 3.52); p = 0.42
Daily seizures (1 if present; 0 otherwise)	1.39 (0.41 to 4.74); p = 0.60	1.45 (0.50 to 4.25); p = 0.49	1.57 (0.56 to 4.39); p = 0.39
Number of AEDs	0.39 (0.20 to 0.78); p = 0.008	0.47 (0.25 to 0.86); p = 0.01	0.49 (0.27 to 0.88); p = 0.02
Affected hemisphere (1 if left; 0 if right)	0.69 (0.25 to 1.95); p = 0.49	0.86 (0.34 to 2.18); p = 0.75	0.75 (0.29 to 1.90); p = 0.54
MRI lesion (1 if present; 0 otherwise)	1.20 (0.41 to 3.44); p = 0.74	0.97 (0.37 to 2.52); p = 0.94	1.36 (0.55 to 3.38); p = 0.51
Habitual clinical seizures during ECoG (1 if present; 0 otherwise)	3.93 (0.77 to 19.96); p = 0.10	1.16 (0.24 to 5.52); p = 0.85	not incorporated
Incomplete SOZ resection (1 if incomplete; 0 otherwise)	0.03 (0.005 to 0.17); p = 0.0001	0.10 (0.03 to 0.36); P = 0.0005	not incorporated
Extra-temporal lobe resection (1 if involved; 0 otherwise)	1.33 (0.43 to 4.14); p = 0.62	1.35 (0.46 to 3.96); p = 0.58	0.85 (0.31 to 2.34); p = 0.76
Size of resection (%)	0.98 (0.95 to 1.01); p = 0.25	0.99 (0.97 to 1.01); p = 0.44	0.97 (0.95 to 1.00); p = 0.04
Subtraction MI z-score	1.45 (1.08 to 1.94); p = 0.01	not incorporated	1.23 (1.00 to 1.53); p = 0.05

Predictor variable

Full model

Odds ratio
(95%CI);
p-value

Model excluding SOZ

Model excluding MI

Age (years)

1.04

(0.96 to 1.13);

p = 0.30

1.02

(0.95 to 1.10);

p = 0.59

1.05

(0.98 to 1.13);

p = 0.20

Gender

(1 if male; 0 female)

1.36

(0.49 to 3.78);

p = 0.56

1.19

(0.47 to 3.01);

p = 0.71

1.44

(0.59 to 3.52);

p = 0.42

Daily seizures

(1 if present;

0 otherwise)

1.39

(0.41 to 4.74);

p = 0.60

1.45

(0.50 to 4.25);

p = 0.49

1.57

(0.56 to 4.39);

p = 0.39

Number of AEDs

0.39

(0.20 to 0.78);

p = 0.008

0.47

(0.25 to 0.86);

p = 0.01

0.49

(0.27 to 0.88);

p = 0.02

Affected hemisphere

(1 if left; 0 if right)

0.69

(0.25 to 1.95);

p = 0.49

0.86

(0.34 to 2.18);

p = 0.75

0.75

(0.29 to 1.90);

p = 0.54

MRI lesion

(1 if present;

0 otherwise)

1.20

(0.41 to 3.44);

p = 0.74

0.97

(0.37 to 2.52);

p = 0.94

1.36

(0.55 to 3.38);

p = 0.51

Habitual clinical seizures during ECoG

(1 if present; 0 otherwise)

3.93

(0.77 to 19.96); p = 0.10

1.16

(0.24 to 5.52);

p = 0.85

not incorporated

Incomplete SOZ resection

(1 if incomplete;

0 otherwise)

0.03

(0.005 to 0.17);

p = 0.0001

0.10

(0.03 to 0.36);

P = 0.0005

not incorporated

Extra-temporal lobe resection

(1 if involved;

0 otherwise)

1.33

(0.43 to 4.14);

p = 0.62

1.35

(0.46 to 3.96);

p = 0.58

0.85

(0.31 to 2.34);

p = 0.76

Size of resection

(%)

0.98

(0.95 to 1.01);

p = 0.25

0.99

(0.97 to 1.01);

p = 0.44

0.97

(0.95 to 1.00);

p = 0.04

Subtraction MI z-score

1.45

(1.08 to 1.94);

p = 0.01

not incorporated

1.23

(1.00 to 1.53);

p = 0.05

AEDs: antiepileptic drugs. ECoG: electrocorticography. SOZ: seizure onset zone. MI: modulation index. ‘Subtraction MI z-score’ is defined as subtraction of MI z-score averaged across all preserved sites from MI z-score averaged across all resected sites. 95%CI: 95% confidence interval.