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. 2019 Nov 22;9:17361. doi: 10.1038/s41598-019-53984-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Integrin signaling pathway of 231 vs. 231BR. Green color denotes the down-regulation of genes in 231, and up-regulation in 231BR. The down-regulation of integrin in 231 (up-regulation in 231BR) may affect the cell adhesion, activation, invasion and mobility functions. The inserted table depicts the expression changes of essential integrin genes in 231 vs. 231BR.