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. 2019 Nov 22;9:17358. doi: 10.1038/s41598-019-53711-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Association between ctDNA response and clinical response after chemotherapy. (A) ctDNA response (after/before ratios of ctDNA levels 8 weeks after initiation of the chemotherapy) is significantly associated with objective response in mCRC patients treated with second-line chemotherapy (P = 0.006). (B) ctDNA response strongly correlated with the tumor shrinkage ratio 8 weeks after initiation of the chemotherapy (r = 0.52, P = 0.006). P values were calculated by Spearman correlation method and linear regression was performed.