Table 3:
Results of the meta-analysis: genetic models
| Gene | SNP | Reference Alleles | Number of Studies | Genetic model | Effect size | Heterogeneity | |||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | p-value | I2 (%) | pQ | |||||
| OPRM1 | rs1799971 | G (minor) | 5 (T, Ko, M, Ka, H) | dominant | 1.052 | (0.856, 1.294) | 0.630 | 0 | 0.669 |
| GCH1 | rs3783641 | A (minor) | 3 (B, M, H) | additive | 1.123 | (0.908, 1.390) | 0.285 | 60.7 | 0.079 |
| COMT | rs4680 | A (minor) | 5 (Hi, T, Ko, M, H) | additive | 1.012 | (0.855, 1.198) | 0.888 | 65.9 | 0.019 |
| COMT | rs4680 | A (minor) | dominant | 1.028 | (0.862, 1.228) | 0.757 | 50.9 | 0.086 | |
| COMT | rs4680 | A (minor) | recessive | 1.058 | (0.884, 1.264) | 0.541 | 64.0 | 0.025 | |
| COMT | rs6269 | G (minor) | 2 (B, M) | additive | 0.993 | (0.845, 1.169) | 0.935 | 79.7 | 0.026 |
| KCNS1 | rs734784 | G (minor) | 2 (L, C) | additive | 1.511 | (1.000, 2.284) | 0.050 | 0 | 0.344 |
| TNF-alpha/TNFA | rs1800629 | G (major) | 2 (M, Ka) | allelic | 1.240 | (0.963, 1.597) | 0.096 | 73.2 | 0.054 |
I2: ratio of excess heterogeneity (observed total variation – expected variation) to total variation in observed effects; OR: odds ratio; CI: confidence interval
pQ: p-value of the Q statistics, weighted sum of squares of the deviation of each observed effect size from the mean effect size.
T: Thomazeau 2016, Ko: Kolesnikov 2013, M: Montes 2015, Ka: Kaliomaki 2016; H: Hegarty 2012, Hi: Hickey 2011; B: Belfer 2015; L: Langford 2015, C: Costigan 2010.