Table 3.
Associations between each characteristic and z-log transformed CSF neurofilament light chain, total tau, and neurogranin after adjustment for age and sex
| Neurofilament light | Total tau | Neurogranin | ||||
|---|---|---|---|---|---|---|
| Characteristics | b (se) | P value | b (se) | P value | b (se) | P value |
| Education, per year | 0.02 (0.01) | .165 | −0.02 (0.01) | .134 | −0.01 (0.01) | .279 |
| Presence of APOE ε4 allele | 0.13 (0.07) | .067 | 0.15 (0.07) | .037 | 0.14 (0.08) | .079 |
| Body Mass Index | −0.01 (0.01) | .060 | −0.02 (0.01) | .012 | −0.01 (0.01) | .134 |
| Gait speed | −0.04 (0.15) | .766 | 0.15 (0.15) | .312 | 0.38 (0.16) | .018 |
| Beck Depression Inventory | 0.04 (0.11) | .725 | 0.08 (0.12) | .461 | 0.10 (0.12) | .416 |
| Beck Anxiety Inventory | 0.003 (0.01) | .703 | 0.001 (0.01) | .840 | −0.002 (0.01) | .796 |
| Ever smoker | −0.17 (0.06) | .006 | 0.001 (0.07) | .992 | 0.04 (0.07) | .605 |
| Charlson comorbidity index | 0.001 (0.01) | .939 | −0.001 (0.01) | .945 | 0.01 (0.01) | .558 |
| Hypertension | 0.05 (0.07) | .513 | −0.08 (0.07) | .283 | −0.001 (0.08) | .993 |
| Dyslipidemia | −0.05 (0.08) | .544 | −0.16 (0.08) | .054 | −0.13 (0.09) | .146 |
| Diabetes | 0.13 (0.08) | .124 | 0.10 (0.09) | .242 | 0.09 (0.09) | .340 |
| Stroke | 0.07 (0.20) | .698 | −0.33 (0.20) | .107 | −0.31 (0.22) | .157 |
| Myocardial infarction | −0.09 (0.10) | .372 | 0.10 (0.11) | .353 | 0.02 (0.11) | .833 |
| Atrial Fibrillation | −0.09 (0.13) | .486 | −0.001 (0.13) | .997 | −0.07 (0.15) | .637 |
| Spinal Stenosis | −0.11 (0.11) | .327 | −0.07 (0.12) | .529 | −0.06 (0.12) | .621 |
| Head trauma | −0.09 (0.09) | .332 | 0.03 (0.09) | .767 | 0.02 (0.10) | .834 |
| Cancer | −0.10 (0.08) | .184 | 0.0002 (0.08) | .998 | 0.03 (0.09) | .722 |
| Cancer with chemotherapy vs. no chemotherapy | 0.17 (0.15) | .278 | −0.16 (0.19) | .398 | −0.32 (0.17) | .063 |
| Mild Cognitive Impairment | 0.26 (0.10) | .013 | 0.11 (0.11) | .295 | 0.05 (0.12) | .645 |
| Dementia | 0.35 (0.34) | .298 | 0.19 (0.35) | .577 | −0.08 (0.38) | .825 |
| Global Z-score | −0.10 (0.04) | .014 | −0.04 (0.04) | .284 | −0.05 (0.04) | .252 |
| Memory Z-score | −0.11 (0.04) | .002 | −0.08 (0.04) | .029 | −0.08 (0.04) | .034 |
| Language Z-score | −0.08 (0.04) | .023 | −0.07 (0.04) | .077 | −0.04 (0.04) | .273 |
| Attention Z-score | −0.03 (0.04) | .444 | 0.01 (0.04) | .746 | 0.02 (0.04) | .645 |
| Visuospatial Z-score | −0.04 (0.04) | .244 | 0.01 (0.04) | .834 | −0.03 (0.04) | .444 |
| CSF NfL | 0.28 (0.04) | <.0001 | 0.28 (0.04) | <.0001 | ||
| CSF Total Tau | 0.27 (0.03) | <.0001 | 0.80 (0.03) | <.0001 | ||
| CSF Neurogranin | 0.23 (0.03) | <.0001 | 0.68 (0.02) | <.0001 | ||
| CSF Amyloid-beta 42 | 0.09 (0.03) | .004 | 0.30 (0.03) | <.0001 | 0.30 (0.03) | <.0001 |
Abbreviations: APOE, apolipoprotein E; NfL, neurofilament light; SE, standard error.
CSF Neurofilament light chain, total tau, and neurogranin were log-transformed and z-scored in order to compare the coefficients. Models including cognitive variables also adjusted for education.