Table 3.
Extracted data from the selected studies
| Study | Year | Region | Type of samples | Method | Sample size | Genotype frequency | p HWE | Allele frequency (%) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | Cases | Controls | |||||||||||||||
| Cases | Controls | Cases | Controls | A/A | A/P | P/P | A/A | A/P | P/P | G | C | G | C | |||||
| Faghani et al. (14) | 2007 | Isfahan | Tissue | Blood | AS-PCR | 51 | 51 | 44 | 6 | 1 | 22 | 27 | 2 | 0.19 | 92.1 | 7.8 | 69.6 | 30.4 |
| Khadang et al. (15) | 2007 | Shiraz | Blood | Blood | AS-PCR | 221 | 205 | 83 | 109 | 29 | 75 | 90 | 40 | 0.39 | 62.2 | 37.8 | 58.5 | 41.5 |
| Faghani et al. (16) | 2008 | Isfahan | Tissue | Blood | AS-PCR | 96 | 96 | 68 | 21 | 7 | 35 | 44 | 17 | 0.88 | 81.7 | 18.2 | 59.4 | 40.6 |
| Kazemi et al. (17) | 2009 | North of Iran | Tissue | Blood | AS-PCR | 42 | 60 | 6 | 30 | 6 | 12 | 45 | 0 | 0 | 50 | 50 | 39.5 | 60.5 |
| Doosti et al. (18) | 2011 | Isfahan | Blood | Blood | PCR-RFLP | 135 | 140 | 52 | 70 | 13 | 36 | 82 | 22 | 0.09 | 64.4 | 35.6 | 55 | 45 |
| Hossein Pour Feizi et al. (19) | 2012 | Tabriz | Blood | Blood | AS-PCR | 126 | 99 | 56 | 44 | 26 | 30 | 50 | 19 | 0.97 | 61.9 | 38.1 | 55.6 | 44.4 |
| Golmohammadi and Namazi (20) | 2013 | Sabzevar | Blood | Blood | AS-PCR | 80 | 80 | 29 | 49 | 2 | 15 | 51 | 14 | 0.04 | 66.8 | 33.2 | 50.6 | 49.4 |
| Rouhi Boroujeni et al. (21) | 2013 | Isfahan | Blood | Blood | PCR-RFLP | 135 | 150 | 27 | 102 | 6 | 36 | 93 | 21 | 0.01 | 57.8 | 42.2 | 55 | 45 |
| Behfarjam et al. (22) | 2013 | Mahabad | Blood | Blood | PCR-RFLP | 25 | 30 | 9 | 14 | 2 | 9 | 17 | 4 | 0.66 | 64 | 36 | 58.3 | 42.7 |
| Sheikhpour and Taghipour Zahir (23) | 2014 | Yazd | Blood | Blood | AS-PCR | 104 | 104 | 51 | 31 | 22 | 22 | 54 | 28 | 0.91 | 63.9 | 36.1 | 47.1 | 52.9 |
| Saadatian et al. (24) | 2014 | Tabriz | Blood | Blood | PCR-RFLP | 100 | 100 | 22 | 48 | 30 | 13 | 63 | 24 | 0.02 | 46 | 54 | 44.5 | 55.5 |
| Gohari-Lasaki et al. (25) | 2015 | Tabriz | Blood | Blood | PCR-RFLP | 100 | 100 | 31 | 48 | 21 | 31 | 57 | 12 | 0.18 | 55 | 45 | 59.5 | 40.5 |
| Ahangar Oskouee et al. (26) | 2015 | Tabriz | Tissue | Tissue | PCR-RFLP | 65 | 65 | 21 | 40 | 4 | 48 | 13 | 4 | 0.11 | 63.1 | 36.9 | 83.8 | 16.2 |
| Rajabi Firoozabadi et al. (27) | 2016 | Yazd | Blood | Blood | AS-PCR | 90 | 83 | 10 | 45 | 35 | 21 | 37 | 25 | 0.62 | 36.1 | 63.9 | 47.5 | 52.5 |
| Moradinasab et al. (28) | 2017 | Bushehr | Blood | Blood | PCR-RFLP | 144 | 162 | 46 | 68 | 30 | 50 | 90 | 22 | 0.18 | 55.6 | 44.4 | 58.6 | 41.4 |
| Pouladi et al. (29) | 2018 | Tabriz | Tissue | Blood | AS-PCR | 143 | 160 | 63 | 54 | 26 | 54 | 74 | 32 | 0.77 | 62.9 | 37.1 | 56.8 | 43.2 |
| Our study | 2018 | Northeast of Iran | Blood | Blood | AS-PCR | 308 | 314 | 187 | 94 | 27 | 189 | 101 | 24 | 0.14 | 76 | 24 | 76.2 | 23.8 |
| Total (17 studies) | 1965 | 1999 | 805 | 873 | 287 | 698 | 988 | 310 | 0.43 | 63.4 | 36.6 | 59.7 | 40.3 | |||||
AS-PCR; Allele specific polymerase chain reaction, RFLP; Restriction fragment length polymorphism, and HWE; Hardy-Weinberg.