Table 3.
Preferred terms retrieved from FAERS reports for Z-drugs.
| # | Eszopiclone (n=458) | Zaleplon (n=77) | Zolpidem (n=3448) | |||
| Preferred term | n (%) | Preferred term | n (%) | Preferred term | n (%) | |
| 1 | Drug ineffective | 78 (17.0) | Drug ineffective | 18 (23) | Drug ineffective | 499 (14.5) |
| 2 | Insomnia | 33 (7.2) | Drug effect incomplete | 3 (4) | Insomnia | 146 (4.2) |
| 3 | Product substitution issue | 30 (6.6) | Insomnia | 3 (4) | Product substitution issue | 96 (2.8) |
| 4 | Dysgeusia | 22 (4.8) | Product quality issue | 3 (4) | Somnambulism | 75 (2.2) |
| 5 | Product quality issue | 16 (3.5) | Product substitution issue | 3 (4) | Somnolence | 59 (1.7) |
| 6 | Drug effect decreased | 14 (3.1) | Abnormal behavior | 2 (3) | Drug dependence | 57 (1.7) |
| 7 | Delirium | 12 (2.6) | Drug hypersensitivity | 2 (3) | Amnesia | 51 (1.5) |
| 8 | Headache | 7 (1.5) | Malaise | 2 (3) | Road traffic accident | 48 (1.4) |
| 9 | Nausea | 7 (1.5) | Nausea | 2 (3) | Toxicity to various agents | 47 (1.4) |
| 10 | Sleep disorder | 7 (1.5) | Nightmare | 2 (3) | Overdose | 46 (1.3) |