Table 3:

Key points in treatment advances for gastroparesis

Tricyclic antidepressants like Nortriptyline and Amitriptyline are ineffective for gastroparesis. Antiemetic NK1 receptor antagonists like Aprepitant and a newer agent Tradipitant appear to be effective for at least some of the cardinal symptoms of gastroparesis. Prokinetic serotonergic agents like Prucalopride might be effective for gastroparesis. Fundic relaxants like Buspirone and Acotiamide are under further investigation for gastroparesis patients. No current controlled evidence for immune-based therapies in gastroparesis exists and is needed. Pyloric therapies may be effective for a subset of patients. However, more work needs to be done to select the patient subgroup with pyloric dysfunction and determine long-term efficacy in controlled studies.