Table 1.

Effects of ATGL deficiency in mice on lipid metabolism across various tissues compared to control littermates

Tissue of Interest
Tissue-knockout	Liver	WAT	BAT	Heart	Skeletal Muscle
Globala	TG accumulation Decreased TG synthesis Decreased FFA oxidation	TG accumulation Decreased TG synthesis	TG accumulation Decreased TG synthesis No change in FFA oxidation	TG accumulation Decreased TG synthesis Decreased FFA oxidation	TG accumulation Decreased FFA oxidation
Liverb	TG accumulation Decreased TG synthesis Decreased FFA oxidation	No change	No change	No change	No change
Adiposec	Decreased fasting TG	TG accumulation Decreased TG synthesis	TG accumulation Decreased TG synthesis	No change	No change
BATd	Unknown	No change	TG accumulation Decreased TG synthesis No change in oxidation	Unknown	No change
Hearte	Unknown	Unknown	Unknown	TG accumulation Decreased TG synthesis Decreased FFA oxidation	No Change
Skeletal musclef	Unknown	Unknown	Unknown	Unknown	TG accumulation
Pancreasg	Unknown	Increased TG lipolysis	Increased FFA oxidation	Unknown	Unknown

^a key reference: [15], ^b key references: [55, 56], ^c key references: [28, 33, 34], ^d key references: [31, 32], ^e key references: [17–20], ^f key references: [36, 39, 47], ^g key references: [25, 61, 62]