Table 2.

Effects of ATGL deficiency in mice on glucose metabolism across various tissues compared to control littermates

Tissue of Interest
Tissue-knockout	Liver	WAT	BAT	Heart	Skeletal muscle
Globala	Increased gluconeogenesis Decreased fasting glycogen	Increased uptake Increased glucose oxidation	Increased glucose oxidation	Decreased glycolysis	Increased glucose oxidation
Liverb	No change	No change	No change	No change	No change
Adiposec	Increased gluconeogenesis Decreased glycogen levels	Increased glucose uptake	Increased glucose oxidation	Increased glucose oxidation	Increased glucose oxidation
BATd	Unknown	Unknown	No change	Unknown	No change
Hearte	Unknown	Unknown	Unknown	Decreased glycolysis	No change
Skeletal musclef	No change	No change	No change	No change	No change
Pancreasg	Unknown	Unknown	Unknown	Unknown	Unknown

^a key reference: [15], ^b key references: [55, 56], ^c key references: [28, 33, 34], ^d key references: [31, 32], ^e key references: [17–20], ^f key references: [36, 39, 47], ^g key references: [25, 61, 62]