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. 2019 Nov 22;12:121. doi: 10.1186/s13045-019-0805-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Regulation of circRNAs by m6A modifications. The regulatory mechanism through which m6A modifications affect circRNA occurs in the cytoplasm. CircRNA is regulated by the demethylase FTO and methyltransferase complex METTL3/14. Methyltransferase complex METTL3/14 induces m6A methylation modifications of circRNA, while the demethylase FTO removes m6A methylation of circRNA. YTHDF3 recognizes the m6A methylation site and then recruits eIF4G2 to the circRNA, thus leading to circRNA translation. Therefore, circRNAs can be modified by m6A, and the methylated circRNAs show protein-encoding ability.