Table 2.
Effects of LCFAs on immunity cells in IBD.
| Effects of LCFAs on immune cells | The type of LCFAs | Role |
|---|---|---|
| Neutrophils | n-6 PUFAs | Inhibit neutrophil infiltration |
| DHA and EPA | Inhibit neutrophil infiltration | |
| n-3 PUFAs | Avert the concomitant hurt caused by neutrophil production | |
| Dendritic cells | n-3 PUFAs | Reduce the antigen-presenting ability of DCs |
| PGE2 | Promote the antigen-presenting ability of DCs | |
| B cells | Palmitic acid and oleic acid | Reduce the immune response ability of B cells |
| n-3 PUFAs | Reduce the immune response ability of B cells, promote intestinal sIgA secretion | |
| T cells | DFO | Reduce the percentage of CD8+ cells, diminish the expression of CD69 on CD4+ T cells, and increase the count of FoxP3+ CD25+ T cells |
| n-3 PUFAs | Reduce the activated cytokines of Th17 cells | |
| Eicosanoids | Decrease the percentage of Th17 cells |