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. 2019 Oct 30;2019:8732023. doi: 10.1155/2019/8732023

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Copyright © 2019 Xiaoyu Xi et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

DNA methylation associated with ovarian aging. (a) DNA methylation levels between both ovarian development stages. YP-1and YP-2 represent sample 1 and sample 2 from young sows at the puberty stage, respectively; OP-1 and OP-2 represent sample 1 and sample 2 from old sows at the reproductive exhaustion stage, respectively. (b) Distribution of CG methylation reads on and around the gene body region. Abbreviations: TSS, transcription start site; TTS, transcription termination site. Gene ontology (GO) function enrichment of the (c) hypermethylated genes and (d) hypomethylated genes related to the different methylation regions (DMRs).