. Author manuscript; available in PMC: 2020 Dec 1.

Published in final edited form as: Hum Mutat. 2019 Sep 10;40(12):2393–2413. doi: 10.1002/humu.23895

Table 6.

Predicted synaptic and non-synaptic changes of M2 variants relative to WT

	Synaptic charge transfer	Non-synaptic charge transfer
WT GluN1/WT 2A	1.0	1.0
1-G618R/2A	--	--
1-G620R/2A	0.2	0.1
2A-L611Q	55	95
2A-N614S	--	--
2A-N615K	24	49

WT GluN1/WT 2B	1.0	1.0
2B-W607C	7.0	3.6
2B-G611V	28	18
2B-N615I	17	24
2B-N615K	21	32
2B-N616K	50	47
2B-V618G	--	--
2B-V620M	8.6	16

The values were calculated by Equations 8–10 and indicate the fold difference in synaptic and non-synaptic function for the variants relative to the corresponding WT receptors (set as 1.0).